PhD Thesis Hans Smit: Fewer cleft births after screening
28-01-2026
At the University of Amsterdam, Hans Smit of the Dutch Fetal Biobank team recently defended his PhD thesis, presenting nine publications on cleft lip and palate in the Netherlands. His research shows that since the introduction of the 20-week ultrasound, fewer children are born with a cleft lip, with or without cleft palate. This is notable, as these conditions are often treatable and many children achieve a good quality of life.
With the earlier introduction of the 13-week ultrasound and changes in reflection periods, anomalies are detected increasingly early. This development calls for careful attention to counseling, time for reflection, and informed decision-making. Screening is not only about technology, but also about how we organize care and support families.
At the same time, Hans demonstrates that submucous cleft palate is frequently diagnosed too late, often around three years of age. Earlier recognition could significantly improve speech and developmental outcomes.
Conducted partly during the COVID-19 pandemic, his work reflects resilience and adaptability. This dissertation contributes to an important societal discussion about prenatal screening, pediatric care, and our shared responsibility in guiding families through complex decisions.
Congratulations Hans!



Publication: Early thyroid development in Down syndrome
We are pleased to share a new publication in Human Molecular Genetics that sheds light on why thyroi…
Read moreA Milestone: 100 Scientific Publications!
I’m proud to share my 100th scientific publication: a review paper on an incredibly important yet st…
Read moreThe 4D Embryonic Brain Atlas
Dr. de Bakker and colleagues have published the 4D Human Embryonic Brain Atlas (8–12 weeks), a spati…
Read more






