It is only after the decision of the parents to terminate their pregnancy, that the gynecologist will provide the option to donate the embryo or fetus to science, as an alternative to cremation or burial. If the parents are open for this option the gynecologist will explain and discuss the procedure and consequences of donating an embryo or fetus to science. All embryos and fetus, whether effected or not by an aneuploidy, are in principle eligible for donation.
If all questions have been answered and the parents decide to donate, the procedure will be initiated. The parents need to complete and sign the forms to specify the donation. After delivery and private moments, the child will be transferred to the Dutch Fetal Biobank. This is also the last moment that the parents can refrain from donation. After transfer to the Biobank, the embryo/fetus is completely anonymized, meaning that no personal data are provided to or stored by the Biobank except of the karyogram and estimated age. The material is from this moment available for scientific research.
If researchers have an interest in the material, they need submit an application which is judged by an independent scientific ethical committee, comprising a medical specialist, an ethicist, a jurist and a member that represents the parents. The registration number of the ethical committee is METC2016_285. The application will be judged on scientific quality, whether the proposed use is within the Dutch law, and whether the material will be used in a respectful way. Moreover, material will not be provided to a commercial enterprise.